Tailored group exercise (Falls Management Exercise -- FaME) reduces falls in community-dwelling older frequent fallers (an RCT).

Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer.son MT. Long-term follow-up of a prospective, double-blind, placebo-controlled randomised trial of clodronate in multiple myeloma. A. Using bisphosphonates to control the pain of bone metastases: evidence-based guidelines for pallia-tive care. Palliat Med 2000; 14: 455–61. 11. Johnson IS. Use of bisphosphonates for the treatment of met-astatic bone pain. A survey of palliative physicians in the UK. Fedeli L et al. Cyclical clodronate's effective in preventing postmenopausal bone loss: a comparative study with transcutaneous hormone replacement therapy. Clodronate reduces ver-tebral fracture risk in women with postmenopausal or secondary osteoporosis: results of a double-blind, placebo-controlled 3-year study. Effect of alendro-nate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Interven-Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis. Inflammation 2004; 28: 15–21. 24. Russell RG, Rogers MJ, Frith JC et al. The pharmacology of bisphosphonates and new insights into their mechanisms of action. Effects of 4-year treatment with once-weekly clodro-nate on prevention of corticosteroid-induced bone loss and fractures in patients with arthritis: evaluation with dual-energy X-ray absorptiometry and quantitative ultrasound. Bone 2003; 33: 575–81. 27. Varenna M, Zucchi F, Ghiringhelli D et al. Intravenous clodro-nate in the treatment of reflex sympathetic dystrophy syndrome. A randomized, double blind, placebo controlled study. The effects of clodr-onate on increased bone turnover and bone loss due to ova-riectomy in rats. SIR—Frequent or recurrent fallers are more likely to have chronic medical conditions and physiological impairments, exhibit functional decline and have poor outcomes, than single fallers [1]. Fractures are also more common in recurrent fallers than single fallers [2]. Modern surgery for hip fracture can no longer improve on its outcomes [3] and therefore, effective prevention of falls [4, 5] is the key to preventing disability and death. There is still no published evidence that a single intervention (tailored group exercise) can prevent falls or injuries in a high risk group of frequent fallers. This randomised controlled trial (RCT) aimed to investigate the impact of a 36 week individualised and tailored group and home exercise intervention, compared with a control intervention, in reducing falls and injuries in community-dwelling, independent-living, frequent falling women aged 65 years …